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KMID : 1134120210240050481
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Journal of Breast Cancer
2021 Volume.24 No. 5 p.481 ~ p.490
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Successful Pre-Operative Local Control of Skin Invasion of Breast Cancer Using a Combination of Systemic Chemotherapy and Mohs Paste
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Takeuchi Masahiro
Katsuki Takefumi
Yoshida Kumiko
Onoda Masahiko
Iwamura Michinori
Inokuchi Toshihiro
Furutani Akira
Katoh Tomoe
Kawano Kazuaki
Hirata Keiji
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Abstract
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Locally advanced breast cancer (tumor > 5 cm, widespread infiltration of the skin and muscle, or metastases to lymph nodes) is difficult to resect by surgery, and even when it is resectable, there is a high probability of local recurrence and distant metastasis. Therefore, systemic therapy should be administered first. However, as cutaneous infiltration progresses, the patient's quality of life is impaired by pain, bleeding, presence of exudates, and a foul-smelling odor. Treatment with Mohs paste with systemic therapy can control symptoms associated with skin infiltration and can also be expected to decrease tumor volume. Herein, we report a case in which a tumor was resected following Mohs paste and systemic chemotherapy administration, and the skin defect was reconstructed with a latissimus dorsi myocutaneous flap. We also review the literature for previously reported cases of breast cancer involving Mohs paste.
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KEYWORD
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Breast neoplasms, Drug therapy, General surgery, Myocutaneous flap, Zinc
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